IC-3Rs Symposium 2022
The Innovation Centre-3Rs (IC-3Rs) at the Vrije Universiteit Brussel (VUB) organizes its 6th IC-3Rs Symposium on September 21st 2022 from 9 till 16.30 on the VUB Health Campus - Auditorium Vanden Driessche.
Antibodies development and production: do we still need animals?
Antibodies are binding molecules (affinity reagents) that have a high specificity for their unique target (antigen). They are essential, not only for our immune system to identify and neutralize bacteria and viruses, but they have important applications in diagnostics, medical use, disease therapy, prenatal therapy, regulatory procedures and not to forget they are an important research tool.
The generation of monoclonal and polyclonal antibodies is still today often done in animals using the in vivo (ascites) production method, which is a painful and stressful technique for experimental animals. Recent EU statistical information on the use of animals for scientific purposes even shows an increase by 65% in the use of animals for monoclonal antibody production by the mouse ascites method between 2015 (27333 animals used) and 2017 (45024 animals used).
As a number of scientifically sound animal-free techniques became available for the development and production of antibodies, questions are posed about ethics, feasibility, scientific background, economics, etc. Recently, the discussion around this topic peaked when recommendations on the use of non-animal-derived antibodies were published by EURL ECVAM*. Indeed, Directive 2010/63/EU on the protection of animals used for scientific purposes does not allow the use of animal-based methods when alternative methods that do not need animal use become available.
In the discussion, a clear difference should be made between monoclonal antibodies and polyclonal antibodies. During the 6th IC-3Rs Symposium, pros and cons will be discussed by two international experts in the field, Prof Stefan Dübel and Prof Gilbert Schönfelder.
*EURL ECVAM recommendation on non-animal-derived antibodies; European Commission, Joint Research Centre, Barroso, J., Halder, M., Whelan, M., EURL ECVAM recommendation on non-animal derived antibodies, Publications Office 2020. https://data.europa.eu/doi/10.2760/80554
Symposium Registration form
Poster Awards IC-3Rs Symposium
1 jury prize of 250€ for the best Video Pitch
1 public prize of 250€ for the best Poster presentation
All submitted poster abstracts will be published in the special Symposium 2022 booklet and the video pitches will be posted on the IC-3Rs website, with your agreement.
Poster viewing and voting will be organized during the walking lunch of the Symposium. All attendees are invited to vote for their favorite poster. A QR code to the voting form will be available onsite and in the Symposium booklet.
The winners of the prizes will be announced during the award ceremony and are expected to give a short pitch presentation.
Topics of interest
Scientists working on the 3R Principle in its broadest sense are invited to submit an abstract. Topics include, amongst others:
- Drug development and research, toxicology, risk assessment, ….
- Stem cells, organ-on-chip, 2D- and 3D-cultures, in silico modeling, …
- Other Reduction and refinement techniques, …
- Submit an abstract in English of max 300 words in Word format (deadline 01/09/’22)
- Make a 3-minute video pitch (deadline 09/09/’22)
- Make a A1 poster (deadline 21/09/’22)
- Indicate the name, affiliation and contact details of each author
- Register above and indicate your participation to the competition
- Send your abstract by the 1st of September to posters@IC-3Rs.org
- Submit your video pitch via a YouTube or Vimeo link by the 9th of September to posters@IC-3Rs.org for the jury prize
- Bring your printed A1 poster to the symposium for the public prize
- You will be notified about the acceptance of your abstract and further practical details
- Prize winners are expected to give a short pitch about their research work during the award ceremony