IC-3Rs • Innovation Centre for 3R Alternatives

8th IC-3Rs Symposium 2025

Monday 15 September 2025

On September 15th, we proudly hosted the 8th edition of the IC-3Rs Symposium, themed “Tools in Action: Driving Better 3Rs Science.” The event was fully booked, welcoming more than 200 leading experts, young researchers, and industry partners for a full day of scientific exchange focused on concrete, high-impact tools that are shaping the future of science and the advancement of the 3Rs.

We were honoured to feature an exceptional lineup of speakers who presented some examples of the 3Rs in action from advanced multi-organ-on-chip models (Reyk Horland), Next-generation risk assessment strategies for skin sensitization of feminine products (Quinten Marcelis), Database for animal-free antibodies (Esther Wenzel) and Virtual control groups (Thomas Steger-Hartmann) to VR in equine surgery (Dimitri Kadic), AI powered pain scoring in animals (Albert Ali Salah) and an update on the RE-Place database (Maude Everaert).

A special congratulation goes to Bieke Bekaert, winner of the poster competition, for her outstanding work entitled: “Efficient evaluation of therapeutic compounds for Charcot-Marie-Tooth disease using patient-derived neuromuscular organoids.”

We also applaud all young scientists who presented posters — your enthusiasm and research excellence enriched the symposium. We are already looking forward to the next edition of the IC-3Rs Symposium.

Programme of the 2025 Symposium

Our 2025 Speakers

Maude Everaert

Vrije Universiteit Brussel, BE

After completing a Master’s degree in Biomedical Sciences at the University of Mons and gaining initial experience in clinical trials at the Military Hospital in Brussels, Maude Everaert joined the Vrije Universiteit Brussel (VUB) in 2022 within the In Vitro Toxicology and Dermato-Cosmetology (IVTD) Department. 

She works as a scientist on the RE-Place Project, which aims to centralize Belgian expertise in alternative methods to animal testing in a central database. Her responsibilities include expanding and maintaining the database, updating the project website, and engaging with the Belgian scientific community through events and outreach to increase the visibility of the project.

Reyk Horland

TissUse, DE

Reyk studied biotechnology with a focus on medical biotechnology. He received his doctorate degree (summa cum laude) in biotechnology from the Technische Universität Berlin. Early in his career, his research activities focused on adult human stem cells and their application in cell therapies. During his stay at the Department of Medical Biotechnology at TU Berlin he broadened his research activities toward the development of complex 3D tissue models for substance testing.

In 2010, Dr. Horland joined the “Multi-Organ-Chip” project which was awarded funding by the highly prestigious GO-BIO grant of the German Federal Ministry of Education and Research (BMBF). His research responsibilities focused on various aspects of tissue engineering, e.g. in vitro blood vessels for drug screening.

Between 2012 and 2015, Reyk was responsible for all Business Development activities of TissUse GmbH, a spin-off company dedicated to commercializing the results of the GO-BIO “Multi-Organ-Chip” project. There he succeeded in acquiring clients from pharma and cosmetics industry as early adopters of the technology while further developing and strengthening the contract service panel of TissUse. He devised and supervised TissUse HUMIMIC product launch campaign, introducing one of the first Organ-on-a-Chip products to the market in 2014.

In 2015, Dr. Horland was promoted to senior management of TissUse as VP of Business Development. Under his leadership, the company has seen a remarkable annual sales growth rate utilizing its hybrid business model approach of offering customized services and highly innovative products to clients worldwide.

Dr. Horland was appointed CEO of TissUse in October 2020. His business network includes leading pharmaceutical and consumer product companies as well as regulatory authorities and outstanding research institutions worldwide.

Dimitri Kadic

EquiTom, BE

Dimitri graduated as a veterinarian from the University of Ghent, Belgium in 2014.

After completing an internship program in Germany (Tierklinik Lüsche) and another one in the UK (Newmarket Equine Hospital), he started his 3 year residency program in Equine Surgery at the University of Montreal, Canada in 2017. 

He successfully completed the specialty training requirements and examination and got certified as a Diplomate of the American College of Veterinary Surgeons (ACVS) in 2021 and shortly after got the certification of the European College of Veterinary Surgeons (ECVS).

Dimitri reinforces the surgical team of Equitom Equine Clinic since August 2020 and is responsible for the internship program.

Quinten Marcelis

Procter & Gamble, BE

Quinten Marcelis is currently a Toxicologist at Procter & Gamble, having joined the company in 2024. In this role within the Global Product Stewardship team, he has global responsibility for human safety of Hard Surface Cleaners, including products such as Mr. Propre and Viakal. He is also an active member of the P&G Contact Dermatitis Team, working to ensure the safety of P&G’s product portfolio.

Prior to this position, Quinten completed a PhD at VUB, at the In VitroToxico-Dermatocosmetology Department. His research, conducted in collaboration with Sciensano, centered on developing a generic safety assessment strategy for feminine intimate products. This work addressed critical needs from both consumers, industry and regulators regarding chemicals in menstrual hygiene products. 

Quinten has presented his PhD research at various (inter)national conferences and poster sessions, contributing to the dialogue on safety assessment methodologies.

Albert Ali Salah

Universiteit Utrecht, NL

Albert Ali Salah is a professor and chair of Social and Affective Computing at the Information and Computing Sciences Department of Utrecht Univ. He obtained his PhD in 2007 from Bogazici University, and worked at CWI, University of Amsterdam, Nagoya University, and Bogazici University, before initiating the Social and Affective Computing group at Utrecht. His research is broad, but mainly uses pattern recognition and machine learning for computer analysis of human behavior. He is a member of the AI and Animal Welfare Lab at Utrecht University, which is a collaboration between ICS and Veterinary Sciences. He currently serves in the Steering Boards of ACM ICMI and IEEE FG conferences, as an associate editor of journals Pattern Recognition and Int. Journal on Human-Computer Studies, and as VP Conferences for the IEEE Biometrics Council. He is a Senior Member of IEEE and ACM.

Thomas Steger-Hartmann

Bayer, DE

Dr. Thomas Steger-Hartmann (VP) led the department Investigational Toxicology and subsequently the In Vitro Safety Subcluster at Bayer AG, Pharmaceuticals, Germany until September 2024. Thomas has more than 29 years of experience in the field of preclinical assessment of pharmaceuticals. He is a trained biologist with a diploma from the University of Freiburg i.Br., an M.Sc. degree from the University of Michigan and a PhD from the University of Freiburg i.Br., Germany. He is a Eurotox registered toxicologist.

Thomas was deputy leader of two European Innovative Medicines Initiative (IMI) projects (eTox and eTransafe) which focussed on data science approaches for preclinical safety assessment. Since September 2024 Thomas leads a a new consortium under the Innovative Health Initiative (IHI) for the advancement of virtual control groups with the name VICT3R (“VICTER”), contributing to the reduction of animal use in safety studies.

Esther Wenzel

Abcalis, DE

Dr. Esther Wenzel is COO and Co-Founder of Abcalis GmbH, a biotechnology spin-off from TU Braun-schweig specializing in the production of fully animal-free antibodies using phage display. She holds a PhD in Biotechnology and brings over two decades of experience in diagnostic test development, cell culture, and innovative animal-free techniques, including 3D cell cultures and spheroids as alterna-tives to animal tissue.

Since the early 2000s, Dr. Wenzel has been committed to advancing non-animal methods in biomedi-cal research. In 2016, she developed fully human, animal-free antibodies against diphtheria toxin, currently under FDA review as a replacement for equine serum therapeutics. She co-invented Mul-ticlonal Antibodies, a standardized, animal-free alternative to polyclonal antibodies, and established high-throughput platforms for functional antibody testing.

To bring these innovations to market, Dr. Wenzel co-founded Abcalis GmbH in 2019. The company has received multiple awards for its work, including the 1st ECEAE prize for Animal-free Antibodies, the Lower Saxony Innovation Award and the Braunschweig Start-up Award. Beyond product development, Dr. Wenzel also offers consulting services to help laboratories transition to animal-origin-free research — supporting ethical, scalable, and reproducible scientific solutions.

Sponsors of the 2025 Symposium